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английски
немски
in·hibi·tor [ɪnˈhɪbɪtəʳ, Am -ɪt̬ɚ] СЪЩ ХИМ
- inhibitor
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ˈfoam in·hibi·tor СЪЩ ТЕХ
- foam inhibitor
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ˈpro·ton pump in·hibi·tor СЪЩ МЕД
"Биология"
competitive inhibitor СЪЩ
- competitive inhibitor
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non-competitive inhibitor
- non-competitive inhibitor
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reverse transcriptase inhibitor СЪЩ
- reverse transcriptase inhibitor
- Reverse Transkriptase-Inhibitor
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едноезични примери (не са проверени от PONS редакцията)
The toxicity is caused by the cyanide ion, which halts cellular respiration by acting as a non-competitive inhibitor for an enzyme in mitochondria called cytochrome c oxidase.
en.wikipedia.org Despite not interacting with the active site, non-competitive inhibitors do reduce the rate of the reaction because they cause the enzyme to change shape.
en.wikipedia.org Among them are the dihydrofolate reductase inhibitors such as trimethoprim, pyrimethamine, and methotrexate; the sulfonamides (competitive inhibitors of 4-aminobenzoic acid in the reactions of dihydropteroate synthetase).
en.wikipedia.org However, "de novo" resistance to endocrine therapy undermines the efficacy of using competitive inhibitors like tamoxifen.
en.wikipedia.org Often competitive inhibitors strongly resemble the real substrate of the enzyme.
en.wikipedia.org Примери от интернет (не са проверени от PONS редакцията)
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www.roche.com In addition, in rheumatology MabThera/Rituxan in combination with methotrexate is indicated for the treatment of adult patients with severe active rheumatoid arthritis who have had an inadequate response or intolerance to other disease-modifying anti-rheumatic drugs (DMARD) including one or more tumour necrosis factor (TNF) inhibitor therapies.
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In der Rheumatologie ist MabThera/Rituxan ausserdem in Kombination mit Methotrexat für die Behandlung von erwachsenen Patienten mit schwerer aktiver rheumatoider Arthritis angezeigt, die auf andere krankheitsmodifizierende Antirheumatika (DMARD) einschliesslich einer oder mehrerer Therapien mit einem Hemmstoff des Tumornekrosefaktors (TNF) unzureichend angesprochen oder die Behandlung nicht vertragen haben.
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www.mpg.de The treatment with the potent inhibitor reduces the concentration of KRAS in the cell membrane and displaces KRAS to membranes within the cell.
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Die Behandlung mit dem potenten Hemmstoff verringert die Konzentration von KRAS an der Zellmembran und verlagert das Protein an Membranen innerhalb der Zelle.
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www.mpg.de In the case of both of the above drugs, the suppression of certain kinase activity with suitable inhibitors is central to the treatment.
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In beiden Fällen steht die Unterdrückung von bestimmten Kinase-Aktivitäten durch geeignete Hemmstoffe im Mittelpunkt der Behandlung.
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www.uni-kiel.de The structure does not only help to understand the molecular mechanism responsible for APP cleavage, but will also be employed to design highly specific and potent inhibitors, which might turn out as possible medicine for the treatment of neurodegenerative disorders or other diseases.? Original publication:
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Die Kenntnisse der Enzymstruktur nutzen wir nicht nur, um die genauen Mechanismen der APP-Spaltung zu untersuchen, sondern auch um spezielle Hemmstoffe zu designen, die gegen neurodegenerative Krankheiten eingesetzt werden können. “ Originalpublikation:
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www.mpg.de “We initially used a chemical genetics approach and then, step by step, improved the fitting of our inhibitors,” describes Steffen Gaali, post-doctoral student in the project group of Felix Hausch and first author of the current study.
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„Ursprünglich haben wir einen chemisch-genetischen Ansatz verwendet und dann Schritt für Schritt die Bindung unserer Hemmstoffe verbessert“, erläutert Steffen Gaali, Post-Doc in der Projektgruppe von Felix Hausch und Erstautor der vorliegenden Studie.
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